PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.

ABSTRACT: OBJECTIVE:The aim of this study is to identify single-nucleotide polymorphisms (SNPs) influencing blood pressure (BP) response to the ?-blocker atenolol. METHODS:Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study. Forty-two polymorphisms with P less than 10 for association with either diastolic or systolic response to atenolol monotherapy were validated in four independent groups of hypertensive individuals (total n?=?2114). RESULTS:In whites, two polymorphisms near the gene PTPRD (rs12346562 and rs1104514) were associated with DBP response to atenolol (P?=?3.2?×?10 and P?=?5.9?×?10, respectively) with directionally opposite association for response to hydrochlorothiazide in another group of 228 whites (P?=?0.0018 and P?=?0.00012). A different polymorphism (rs10739150) near PTPRD was associated with response to atenolol in 150 black hypertensive individuals (P?=?8.25?×?10). rs12346562 had a similar trend in association with response to bisoprolol (a different ?-blocker) in 207 Finnish men in the genetics of drug responsiveness in essential hypertension study. In addition, an intronic single-nucleotide polymorphism (rs4742610) in the PTPRD gene was associated with resistant hypertension in whites and Hispanics in the international verapamil SR trandolapril study (meta-analysis P?=?3.2?×?10). CONCLUSION:PTPRD was identified as a novel locus potentially associated with BP response to atenolol and resistant hypertension in multiple ethnic groups.

SUBMITTER: Gong Y 

PROVIDER: S-EPMC4788379 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature