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1H, 15N, 13C resonance assignment of human GAP-43.

ABSTRACT: GAP-43 is a 25 kDa neuronal intrinsically disordered protein, highly abundant in the neuronal growth cone during development and regeneration. The exact molecular function(s) of GAP-43 remains unclear but it appears to be involved in growth cone guidance and actin cytoskeleton organization. Therefore, GAP-43 seems to play an important role in neurotransmitter vesicle fusion and recycling, long-term potentiation, spatial memory formation and learning. Here we report the nearly complete assignment of recombinant human GAP-43.

SUBMITTER: Flamm AG

PROVIDER: S-EPMC4788685 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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1H, 15N, 13C resonance assignment of human GAP-43.

Flamm Andrea Gabriele AG Żerko Szymon S Zawadzka-Kazimierczuk Anna A Koźmiński Wiktor W Konrat Robert R Coudevylle Nicolas N

Biomolecular NMR assignments 20160109 1

GAP-43 is a 25 kDa neuronal intrinsically disordered protein, highly abundant in the neuronal growth cone during development and regeneration. The exact molecular function(s) of GAP-43 remains unclear but it appears to be involved in growth cone guidance and actin cytoskeleton organization. Therefore, GAP-43 seems to play an important role in neurotransmitter vesicle fusion and recycling, long-term potentiation, spatial memory formation and learning. Here we report the nearly complete assignment ...[more]

PMID: 26748655

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