Ontology highlight
ABSTRACT:
SUBMITTER: Crisan M
PROVIDER: S-EPMC4788785 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Crisan Mihaela M Solaimani Kartalaei Parham P Neagu Alex A Karkanpouna Sofia S Yamada-Inagawa Tomoko T Purini Caterina C Vink Chris S CS van der Linden Reinier R van Ijcken Wilfred W Chuva de Sousa Lopes Susana M SM Monteiro Rui R Mummery Christine C Dzierzak Elaine E
Stem cell reports 20160225 3
Hematopoietic stem cells (HSC), the self-renewing cells of the adult blood differentiation hierarchy, are generated during embryonic stages. The first HSCs are produced in the aorta-gonad-mesonephros (AGM) region of the embryo through endothelial to a hematopoietic transition. BMP4 and Hedgehog affect their production and expansion, but it is unknown whether they act to affect the same HSCs. In this study using the BRE GFP reporter mouse strain that identifies BMP/Smad-activated cells, we find t ...[more]