Ontology highlight
ABSTRACT:
SUBMITTER: Ye Z
PROVIDER: S-EPMC4788964 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Ye Zhishi Z Gettys Kristen E KE Shen Xingyu X Dai Mingji M
Organic letters 20151204 24
Novel and general copper-catalyzed cyclopropanol ring opening cross-coupling reactions with difluoroalkyl bromides, perfluoroalkyl iodides, monofluoroalkyl bromides, and 2-bromo-2-alkylesters to synthesize various β-(fluoro)alkylated ketones are reported. The reactions feature mild conditions and excellent functional group compatibility and can be scaled up to gram scale. Preliminary mechanistic studies suggest the involvement of radical intermediates. The difluoroalkyl-alkyl cross-coupling prod ...[more]