Ontology highlight
ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC4789669 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Chen Huayan H Yang Hui H Wang Zhilong Z Xie Xin X Nan Fajun F
ACS medicinal chemistry letters 20160122 3
The indole derivative, 3-((E)-3-((3-((E)-2-(7-chloroquinolin-2yl)vinyl)phenyl)amino)-3-oxoprop-1-en-1-yl)-7-methoxy-1H-indole-2-carboxylic acid (17k), was identified as a novel and highly potent and selective CysLT1 antagonist with IC50 values of 0.0059 ± 0.0011 and 15 ± 4 μM for CysLT1 and CysLT2, respectively. ...[more]