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Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging.

ABSTRACT: The detection and imaging of hERG potassium channels in living cells can provide useful information for hERG-correlation studies. Herein, three small-molecule fluorescent probes, based on the potent hERG channel inhibitor astemizole, for the imaging of hERG channels in hERG-transfected HEK293 cells (hERG-HEK293) and human colorectal cancer cells (HT-29), are described. These probes are expected to be applied in the physiological and pathological studies of hERG channels.

SUBMITTER: Wang B

PROVIDER: S-EPMC4789673 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging.

Wang Beilei B Liu Zhenzhen Z Ma Zhao Z Li Minyong M Du Lupei L

ACS medicinal chemistry letters 20160120 3

The detection and imaging of hERG potassium channels in living cells can provide useful information for hERG-correlation studies. Herein, three small-molecule fluorescent probes, based on the potent hERG channel inhibitor astemizole, for the imaging of hERG channels in hERG-transfected HEK293 cells (hERG-HEK293) and human colorectal cancer cells (HT-29), are described. These probes are expected to be applied in the physiological and pathological studies of hERG channels. ...[more]

PMID: 26985309

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