Association of OPN rs11730582 polymorphism with cancer risk: a meta-analysis.

ABSTRACT: PURPOSE:Several molecular epidemiological studies have investigated the association between OPN rs11730582 C>T polymorphism and cancer risk, but the results are inconsistent. Hence, a meta-analysis was conducted to determine the association of this polymorphism with cancer risk. MATERIALS AND METHODS:The related articles were searched in PubMed, Embase, and Chinese National Knowledge Infrastructure databases. Pooled odds ratios and 95% confidence intervals were calculated to evaluate the strength of the associations. A random-effects model or fixed-effects model was employed depending on the heterogeneity. RESULTS:A total of ten case-control studies involving 2,749 cancer cases and 3,398 controls were included in the meta-analysis. In overall analysis, OPN rs11730582 C.T polymorphism was not associated with cancer risk. In a stratified analysis by cancer type, no significant association was found between OPN rs11730582 C>T polymorphism and the risk of glioma, gastric cancer, and other cancers. CONCLUSION:This meta-analysis suggests that OPN rs11730582 C.T polymorphism is not associated with cancer susceptibility.

SUBMITTER: He L 

PROVIDER: S-EPMC4789843 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature