Ontology highlight
ABSTRACT:
SUBMITTER: van den Boom J
PROVIDER: S-EPMC4790943 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
van den Boom Johannes J Trusch Franziska F Hoppstock Lukas L Beuck Christine C Bayer Peter P
PloS one 20160314 3
Type 2 asparaginases, a subfamily of N-terminal nucleophile (Ntn) hydrolases, are activated by limited proteolysis. This activation yields a heterodimer and a loop region at the C-terminus of the α-subunit is released. Since this region is unresolved in all type 2 asparaginase crystal structures but is close to the active site residues, we explored this loop region in six members of the type 2 asparaginase family using homology modeling. As the loop model for the childhood cancer-relevant protea ...[more]