Ontology highlight
ABSTRACT:
SUBMITTER: Sharma A
PROVIDER: S-EPMC7193500 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Sharma Amit A Jyotsana Nidhi N Gabdoulline Razif R Heckl Dirk D Kuchenbauer Florian F Slany Robert K RK Ganser Arnold A Heuser Michael M
Haematologica 20190814 5
Mixed lineage leukemia (<i>MLL/KMT2A</i>) rearrangements (MLL-r) are one of the most frequent chromosomal aberrations in acute myeloid leukemia. We evaluated the function of Meningioma 1 (MN1), a co-factor of HOXA9 and MEIS1, in human and murine MLL-rearranged leukemia by CRISPR-Cas9 mediated deletion of MN1. MN1 was required for <i>in vivo</i> leukemogenicity of MLL positive murine and human leukemia cells. Loss of MN1 inhibited cell cycle and proliferation, promoted apoptosis and induced diffe ...[more]