Ontology highlight
ABSTRACT:
SUBMITTER: Bisson J
PROVIDER: S-EPMC4791574 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20151027 5
High-throughput biology has contributed a wealth of data on chemicals, including natural products (NPs). Recently, attention was drawn to certain, predominantly synthetic, compounds that are responsible for disproportionate percentages of hits but are false actives. Spurious bioassay interference led to their designation as pan-assay interference compounds (PAINS). NPs lack comparable scrutiny, which this study aims to rectify. Systematic mining of 80+ years of the phytochemistry and biology lit ...[more]