Ontology highlight
ABSTRACT:
SUBMITTER: Le LT
PROVIDER: S-EPMC4792073 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Le Lily Thao-Nhi LT Cazares Oscar O Mouw Janna K JK Chatterjee Sharmila S Macias Hector H Moran Angel A Ramos Jillian J Keely Patricia J PJ Weaver Valerie M VM Hinck Lindsay L
The Journal of cell biology 20160301 6
Breast tumor progression is accompanied by changes in the surrounding extracellular matrix (ECM) that increase stiffness of the microenvironment. Mammary epithelial cells engage regulatory pathways that permit dynamic responses to mechanical cues from the ECM. Here, we identify a SLIT2/ROBO1 signaling circuit as a key regulatory mechanism by which cells sense and respond to ECM stiffness to preserve tensional homeostasis. We observed that Robo1 ablation in the developing mammary gland compromise ...[more]