Ontology highlight
ABSTRACT:
SUBMITTER: Stroka KM
PROVIDER: S-EPMC5589558 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Stroka Kimberly M KM Wong Bin Sheng BS Shriver Marey M Phillip Jude M JM Wirtz Denis D Kontrogianni-Konstantopoulos Aikaterini A Konstantopoulos Konstantinos K
Oncotarget 20160801 33
Obscurins are a family of RhoGEF-containing proteins with tumor and metastasis suppressing roles in breast epithelium. Downregulation of giant obscurins in normal breast epithelial cells leads to reduced levels of active RhoA and of its downstream effectors. Herein, we elucidate how depletion of giant obscurins affects the response of breast epithelial cells to changes in the mechanical properties of the microenvironment. We find that knockdown of obscurins increases cell morphodynamics, migrati ...[more]