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Information Limited Oligonucleotide Amplification Assay for Affinity-Based, Parallel Detection Studies.

ABSTRACT: Molecular communication systems encounter similar constraints as telecommunications. In either case, channel crosstalk at the receiver end will result in information loss that statistical analysis cannot compensate. This is because in any communication channel there is a physical limit to the amount of information that can be transmitted. We present a novel and simple modified end amplification (MEA) technique to generate reduced and defined amounts of specific information in form of short fragments from an oligonucleotide source that also contains unrelated and redundant information. Our method can be a valuable tool to investigate information overflow and channel capacity in biomolecular recognition systems.

SUBMITTER: Bokkasam H

PROVIDER: S-EPMC4792472 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Information Limited Oligonucleotide Amplification Assay for Affinity-Based, Parallel Detection Studies.

Bokkasam Harish H Ott Albrecht A

PloS one 20160315 3

Molecular communication systems encounter similar constraints as telecommunications. In either case, channel crosstalk at the receiver end will result in information loss that statistical analysis cannot compensate. This is because in any communication channel there is a physical limit to the amount of information that can be transmitted. We present a novel and simple modified end amplification (MEA) technique to generate reduced and defined amounts of specific information in form of short fragm ...[more]

PMID: 26978653

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