Unknown

Dataset Information

0

IL-17-producing ?? T cells enhance bone regeneration.

ABSTRACT: Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that ?? T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a defect in osteoblastic bone formation. IL-17A accelerates bone formation by stimulating the proliferation and osteoblastic differentiation of mesenchymal progenitor cells. This study identifies a novel role for IL-17-producing ?? T cells in skeletal tissue regeneration.

SUBMITTER: Ono T 

PROVIDER: S-EPMC4792964 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

IL-17-producing γδ T cells enhance bone regeneration.

Ono Takehito T   Okamoto Kazuo K   Nakashima Tomoki T   Nitta Takeshi T   Hori Shohei S   Iwakura Yoichiro Y   Takayanagi Hiroshi H  

Nature communications 20160311

Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not entirely clear. Here we show that γδ T cells produce IL-17A, which promotes bone formation and facilitates bone fracture healing. Repair is impaired in IL-17A-deficient mice due to a  ...[more]

Similar Datasets

Unknown IL-17 and IL-17-producing cells in protection versus pathology.
| S-EPMC9255545 | biostudies-literature
Unknown Interleukin 17-producing γδT cells promote hepatic regeneration in mice.
| S-EPMC4123443 | biostudies-literature
Unknown Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production.
| S-EPMC2799849 | biostudies-other
Unknown IL-17-producing ?? T cells protect against Clostridium difficile infection.
| S-EPMC7190913 | biostudies-literature
Unknown IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells.
| S-EPMC2874584 | biostudies-literature
Unknown Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing ?? cells.
| S-EPMC3491488 | biostudies-literature
Unknown IL-23 receptor regulates unconventional IL-17-producing T cells that control bacterial infections.
| S-EPMC2829977 | biostudies-literature
Unknown Fate mapping of IL-17-producing T cells in inflammatory responses.
| S-EPMC3040235 | biostudies-literature
Unknown Identification of IL-17-producing FOXP3+ regulatory T cells in humans.
| S-EPMC2653560 | biostudies-literature
Unknown Overexpression of hepatic serum amyloid A1 in mice increases IL-17-producing innate immune cells and decreases bone density.
| S-EPMC8086136 | biostudies-literature