Ontology highlight
ABSTRACT:
SUBMITTER: Nakamizo S
PROVIDER: S-EPMC5658347 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nakamizo Satoshi S Honda Tetsuya T Adachi Akimasa A Nagatake Takahiro T Kunisawa Jun J Kitoh Akihiko A Otsuka Atsushi A Dainichi Teruki T Nomura Takashi T Ginhoux Florent F Ikuta Koichi K Egawa Gyohei G Kabashima Kenji K
Scientific reports 20171026 1
Psoriasis is a common, chronic inflammatory skin disease characterized by epidermal hyperplasia via the IL-23/IL-17 axis. Various studies have indicated the association between obesity and psoriasis, however, the underlying mechanisms remains unclarified. To this end, we focused on high-fat diet (HFD) in this study, because HFD is suggested as a contributor to obesity, and HFD-fed mice exhibit exacerbated psoriatic dermatitis. Using murine imiquimod (IMQ)-induced psoriasis and HFD-induced obesit ...[more]