The Hippo pathway member YAP enhances human neural crest cell fate and migration.
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ABSTRACT:
SUBMITTER: Hindley CJ
PROVIDER: S-EPMC4793290 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
The Hippo pathway member YAP enhances human neural crest cell fate and migration.
Hindley Christopher J CJ Condurat Alexandra Larisa AL Menon Vishal V Thomas Ria R Azmitia Luis M LM Davis Jason A JA Pruszak Jan J
Scientific reports 20160316
The Hippo/YAP pathway serves as a major integrator of cell surface-mediated signals and regulates key processes during development and tumorigenesis. The neural crest is an embryonic tissue known to respond to multiple environmental cues in order to acquire appropriate cell fate and migration properties. Using multiple in vitro models of human neural development (pluripotent stem cell-derived neural stem cells; LUHMES, NTERA2 and SH-SY5Y cell lines), we investigated the role of Hippo/YAP signali ...[more]
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