Ontology highlight
ABSTRACT:
SUBMITTER: Sugihara T
PROVIDER: S-EPMC6536462 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Sugihara Takaaki T Isomoto Hajime H Gores Gregory G Smoot Rory R
Journal of gastroenterology 20190227 6
Cholangiocarcinoma (CCA) has an increasing incidence and remains a difficult to treat malignancy. In a search for more effective treatment options, progress has been made in identifying molecular drivers of oncogenic signaling including IDH mutations and FGFR2 fusions. In addition, multiple investigators have identified increased activity of YAP, the effector protein of the Hippo pathway, in CCA. The Hippo pathway regulates organ size, cellular proliferation, and apoptosis via YAP, a transcripti ...[more]