Ontology highlight
ABSTRACT:
SUBMITTER: Cardenas C
PROVIDER: S-EPMC4794382 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Cell reports 20160303 10
In the absence of low-level ER-to-mitochondrial Ca(2+) transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we demonstrate that tumorigenic cancer cell lines, transformed primary human fibroblasts, and tumors in vivo respond similarly but that autophagy is insufficient for survival, and cancer cells die while their normal counterparts are spared. Cancer cell death is due to compromised bioenergetics that ...[more]