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Multi-Shell Hollow Nanogels with Responsive Shell Permeability.

ABSTRACT: We report on hollow shell-shell nanogels with two polymer shells that have different volume phase transition temperatures. By means of small angle neutron scattering (SANS) employing contrast variation and molecular dynamics (MD) simulations we show that hollow shell-shell nanocontainers are ideal systems for controlled drug delivery: The temperature responsive swelling of the inner shell controls the uptake and release, while the thermoresponsive swelling of the outer shell controls the size of the void and the colloidal stability. At temperatures between 32?°C?

SUBMITTER: Schmid AJ

PROVIDER: S-EPMC4794761 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Multi-Shell Hollow Nanogels with Responsive Shell Permeability.

Schmid Andreas J AJ Dubbert Janine J Rudov Andrey A AA Pedersen Jan Skov JS Lindner Peter P Karg Matthias M Potemkin Igor I II Richtering Walter W

Scientific reports 20160317

We report on hollow shell-shell nanogels with two polymer shells that have different volume phase transition temperatures. By means of small angle neutron scattering (SANS) employing contrast variation and molecular dynamics (MD) simulations we show that hollow shell-shell nanocontainers are ideal systems for controlled drug delivery: The temperature responsive swelling of the inner shell controls the uptake and release, while the thermoresponsive swelling of the outer shell controls the size of ...[more]

PMID: 26984478

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