Ontology highlight
ABSTRACT:
SUBMITTER: Zhemkov VA
PROVIDER: S-EPMC4794786 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Zhemkov Vladimir A VA Kulminskaya Anna A AA Bezprozvanny Ilya B IB Kim Meewhi M
FEBS open bio 20160218 3
An expansion of polyglutamine (polyQ) sequence in ataxin-3 protein causes spinocerebellar ataxia type 3, an inherited neurodegenerative disorder. The crystal structure of the polyQ-containing carboxy-terminal fragment of human ataxin-3 was solved at 2.2-Å resolution. The Atxn3 carboxy-terminal fragment including 14 glutamine residues adopts both random coil and α-helical conformations in the crystal structure. The polyQ sequence in α-helical structure is stabilized by intrahelical hydrogen bonds ...[more]