Ontology highlight
ABSTRACT:
SUBMITTER: Karakachoff M
PROVIDER: S-EPMC4795055 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Karakachoff Matilde M Duforet-Frebourg Nicolas N Simonet Floriane F Le Scouarnec Solena S Pellen Nadine N Lecointe Simon S Charpentier Eric E Gros Françoise F Cauchi Stéphane S Froguel Philippe P Copin Nane N Le Tourneau Thierry T Probst Vincent V Le Marec Hervé H Molinaro Sabrina S Balkau Beverley B Redon Richard R Schott Jean-Jacques JJ Blum Michael Gb MG Dina Christian C
European journal of human genetics : EJHG 20140903 6
The difficulties arising from association analysis with rare variants underline the importance of suitable reference population cohorts, which integrate detailed spatial information. We analyzed a sample of 1684 individuals from Western France, who were genotyped at genome-wide level, from two cohorts D.E.S.I.R and CavsGen. We found that fine-scale population structure occurs at the scale of Western France, with distinct admixture proportions for individuals originating from the Brittany Region ...[more]