Ontology highlight
ABSTRACT:
SUBMITTER: Aprile-Garcia F
PROVIDER: S-EPMC4795689 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Aprile-Garcia Fernando F Metzger Michael W MW Paez-Pereda Marcelo M Stadler Herbert H Acuña Matías M Liberman Ana C AC Senin Sergio A SA Gerez Juan J Hoijman Esteban E Refojo Damian D Mitkovski Mišo M Panhuysen Markus M Stühmer Walter W Holsboer Florian F Deussing Jan M JM Arzt Eduardo E
PloS one 20160317 3
The P2X7 receptor is a member of the P2X family of ligand-gated ion channels. A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with mood disorders. No change in function (loss or gain) has been described for this SNP so far. Here we show that although the P2X7R-Gln460Arg variant per se is not compromised in its function, co-expression of wild-type P2X7R with P2X7R-Gln460Arg impair ...[more]