Ontology highlight
ABSTRACT:
SUBMITTER: Xie LG
PROVIDER: S-EPMC4796318 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Xie Lan-Gui LG Niyomchon Supaporn S Mota Antonio J AJ González Leticia L Maulide Nuno N
Nature communications 20160315
Nitrogen-containing heteroaromatic cores are ubiquitous building blocks in organic chemistry. Herein, we present a family of metal-free intermolecular formal cycloaddition reactions that enable highly selective and orthogonal access to isoquinolines and pyrimidines at will. Applications of the products are complemented by a density functional theory mechanistic analysis that pinpoints the crucial factors responsible for the selectivity observed, including stoichiometry and the nature of the hete ...[more]