Ontology highlight
ABSTRACT:
SUBMITTER: Bissonnette NB
PROVIDER: S-EPMC6993613 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Chemical science 20190828 41
A large proportion of medicinally relevant molecules bear nitrogen and sp<sup>3</sup>-hybridized carbon functionalities. Overwhelmingly, these atoms are found as part of (hetero)cyclic structures. Despite their importance, synthetic approaches to saturated nitrogen heterocycles are limited to several established stoichiometric alkylation techniques, as well as a few methods involving C-H bond activation. The synthetic community remains interested in more general, mild, and sustainable ways to ac ...[more]