Ontology highlight
ABSTRACT:
SUBMITTER: Boltengagen M
PROVIDER: S-EPMC4797270 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Boltengagen Mark M Huang Anming A Boltengagen Anastasiya A Trixl Lukas L Lindner Herbert H Kremser Leopold L Offterdinger Martin M Lusser Alexandra A
Nucleic acids research 20151119 5
The incorporation of CENP-A into centromeric chromatin is an essential prerequisite for kinetochore formation. Yet, the molecular mechanisms governing this process are surprisingly divergent in different organisms. While CENP-A loading mechanisms have been studied in some detail in mammals, there are still large gaps to our understanding of CENP-A/Cid loading pathways in Drosophila. Here, we report on the characterization and delineation of at least three different CENP-A preloading complexes in ...[more]