Hydride Reduction by a Sodium Hydride-Iodide Composite.
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SUBMITTER: Too PC
PROVIDER: S-EPMC4797714 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
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Hydride Reduction by a Sodium Hydride-Iodide Composite.
Too Pei Chui PC Chan Guo Hao GH Tnay Ya Lin YL Hirao Hajime H Chiba Shunsuke S
Angewandte Chemie (International ed. in English) 20160216 11
Sodium hydride (NaH) is widely used as a Brønsted base in chemical synthesis and reacts with various Brønsted acids, whereas it rarely behaves as a reducing reagent through delivery of the hydride to polar π electrophiles. This study presents a series of reduction reactions of nitriles, amides, and imines as enabled by NaH in the presence of LiI or NaI. This remarkably simple protocol endows NaH with unprecedented and unique hydride-donor chemical reactivity. ...[more]
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