Ontology highlight
ABSTRACT:
SUBMITTER: Ortega MA
PROVIDER: S-EPMC4798866 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Ortega Manuel A MA Hao Yue Y Walker Mark C MC Donadio Stefano S Sosio Margherita M Nair Satish K SK van der Donk Wilfred A WA
Cell chemical biology 20160211 3
Class I lantibiotic dehydratases dehydrate selected Ser/Thr residues of a precursor peptide. Recent studies demonstrated the requirement of glutamyl-tRNA(Glu) for Ser/Thr activation by one of these enzymes (NisB) from the Firmicute Lactococcus lactis. However, the generality of glutamyl-tRNA(Glu) usage and the tRNA specificity of lantibiotic dehydratases have not been established. Here we report the 2.7-Å resolution crystal structure, along with the glutamyl-tRNA(Glu) utilization of MibB, a lant ...[more]