Ontology highlight
ABSTRACT:
SUBMITTER: Smits MM
PROVIDER: S-EPMC4799913 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Smits Mark M MM Muskiet Marcel H A MH Tonneijck Lennart L Hoekstra Trynke T Kramer Mark H H MH Diamant Michaela M van Raalte Daniël H DH
British journal of clinical pharmacology 20160125 4
<h4>Aim</h4>Clinical use of glucagon-like peptide-1 receptor agonists (GLP-1RA) is consistently associated with heart rate (HR) acceleration in type 2 diabetes patients. We explored the mechanisms underlying this potential safety concern.<h4>Methods</h4>Ten healthy overweight males (aged 20-27 years) were examined in an open label, crossover study. Automated oscillometric blood pressure measurements and finger photoplethysmography were performed throughout intravenous administration of placebo ( ...[more]