Ontology highlight
ABSTRACT:
SUBMITTER: Grebe KM
PROVIDER: S-EPMC2941093 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20091216 2
Although the sympathetic nervous system innervates the lung, little is known about its participation in host immunity to pulmonary pathogens. In this study, we show that peripheral sympathectomy reduces mouse morbidity and mortality from influenza A virus-induced pneumonia due to reduced inflammatory influx of monocytes, neutrophils, and NK cells. Mortality was also delayed by treating mice with an alpha-adrenergic antagonist. Sympathectomy diminished the immediate innate cytokine responses, par ...[more]