Ontology highlight
ABSTRACT:
SUBMITTER: Corrales L
PROVIDER: S-EPMC4800192 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Corrales Leticia L Woo Seng-Ryong SR Williams Jason B JB McWhirter Sarah M SM Dubensky Thomas W TW Gajewski Thomas F TF
Journal of immunology (Baltimore, Md. : 1950) 20160229 7
Recent evidence has indicated that innate immune sensing of cytosolic DNA in dendritic cells via the host STING pathway is a major mechanism leading to spontaneous T cell responses against tumors. However, the impact of the other major pathway triggered by intracellular DNA, the absent in melanoma 2 (AIM2) inflammasome, on the functional output from the stimulator of IFN genes (STING) pathway is poorly understood. We found that dendritic cells and macrophages deficient in AIM2, apoptosis-associa ...[more]