Ontology highlight
ABSTRACT:
SUBMITTER: Dang EV
PROVIDER: S-EPMC5693620 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Dang Eric V EV McDonald Jeffrey G JG Russell David W DW Cyster Jason G JG
Cell 20171012 5
Type I interferon restrains interleukin-1β (IL-1β)-driven inflammation in macrophages by upregulating cholesterol-25-hydroxylase (Ch25h) and repressing SREBP transcription factors. However, the molecular links between lipid metabolism and IL-1β production remain obscure. Here, we demonstrate that production of 25-hydroxycholesterol (25-HC) by macrophages is required to prevent inflammasome activation by the DNA sensor protein absent in melanoma 2 (AIM2). We find that in response to bacterial inf ...[more]