Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers.
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ABSTRACT:
SUBMITTER: Moisan F
PROVIDER: S-EPMC4801026 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
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Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers.
Moisan Francois F Francisco Edgar B EB Brozovic Anamaria A Duran George E GE Wang Yan C YC Chaturvedi Shalini S Seetharam Shobha S Snyder Linda A LA Doshi Parul P Sikic Branimir I BI
Molecular oncology 20140418 7
Ovarian cancer is associated with a leukocyte infiltrate and high levels of chemokines such as CCL2. We tested the hypothesis that CCL2 inhibition can enhance chemotherapy with carboplatin and paclitaxel. Elevated CCL2 expression was found in three non-MDR paclitaxel resistant ovarian cancer lines ES-2/TP, MES-OV/TP and OVCAR-3/TP, compared to parental cells. Mice xenografted with these cells were treated with the anti-human CCL2 antibody CNTO 888 and the anti-mouse MCP-1 antibody C1142, with an ...[more]
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