Ontology highlight
ABSTRACT:
SUBMITTER: Campbell J
PROVIDER: S-EPMC4802229 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Cell reports 20160303 10
One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell lines. Here, we describe data from a series of siRNA screens that identify the kinase genetic dependencies in 117 cancer cell lines from ten cancer types. By integrating the siRNA screen data with molecular profiling data, including exome sequencing data, we show how vulnerabilities/genetic dependencies that are associated with mutations in specific cancer driver ...[more]