Ontology highlight
ABSTRACT:
SUBMITTER: Keswani RK
PROVIDER: S-EPMC4802322 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Keswani Rahul K RK Tian Chao C Peryea Tyler T Girish Gandikota G Wang Xueding X Rosania Gus R GR
Scientific reports 20160322
Photoacoustic Tomography (PAT) is a deep-tissue imaging modality, with potential clinical applications in the diagnosis of arthritis, cancer and other disease conditions. Here, we identified Clofazimine (CFZ), a red-pigmented dye and anti-inflammatory FDA-approved drug, as a macrophage-targeting photoacoustic (PA) imaging agent. Spectroscopic experiments revealed that CFZ and its various protonated forms yielded optimal PAT signals at wavelengths -450 to 540 nm. CFZ's macrophage-targeting chemic ...[more]