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Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.


ABSTRACT:

Objective

High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson's disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between the phase of beta band oscillations and the amplitude of high-frequency oscillations around 300 Hz.

Methods

We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 patients before and/or after taking dopaminergic medication. We correlated mean values of spectral power and phase-amplitude coupling with severity of hemibody bradykinesia/rigidity. In addition, we used simultaneously recorded magnetoencephalography to look at functional interactions between the subthalamic nucleus and ipsilateral motor cortex.

Results

Beta band power and phase-amplitude coupling within the subthalamic nucleus correlated positively with severity of motor impairment. This effect was more pronounced within the low-beta range, whilst coherence between subthalamic nucleus and motor cortex was dominant in the high-beta range.

Conclusions

We speculate that the beta band might impede pro-kinetic high-frequency activity patterns when phase-amplitude coupling is prominent. Furthermore, results provide evidence for a functional subdivision of the beta band into low and high frequencies.

Significance

Our findings contribute to the interpretation of oscillatory activity within the cortico-basal ganglia circuit.

SUBMITTER: van Wijk BC 

PROVIDER: S-EPMC4803022 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Subthalamic nucleus phase-amplitude coupling correlates with motor impairment in Parkinson's disease.

van Wijk Bernadette C M BC   Beudel Martijn M   Jha Ashwani A   Oswal Ashwini A   Foltynie Tom T   Hariz Marwan I MI   Limousin Patricia P   Zrinzo Ludvic L   Aziz Tipu Z TZ   Green Alexander L AL   Brown Peter P   Litvak Vladimir V  

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20160201 4


<h4>Objective</h4>High-amplitude beta band oscillations within the subthalamic nucleus are frequently associated with Parkinson's disease but it is unclear how they might lead to motor impairments. Here we investigate a likely pathological coupling between the phase of beta band oscillations and the amplitude of high-frequency oscillations around 300 Hz.<h4>Methods</h4>We analysed an extensive data set comprising resting-state recordings obtained from deep brain stimulation electrodes in 33 pati  ...[more]

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