Ontology highlight
ABSTRACT:
SUBMITTER: Pickrell AM
PROVIDER: S-EPMC4803114 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Pickrell Alicia M AM Huang Chiu-Hui CH Kennedy Scott R SR Ordureau Alban A Sideris Dionisia P DP Hoekstra Jake G JG Harper J Wade JW Youle Richard J RJ
Neuron 20150701 2
Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. PARK2 mutations cause early-onset forms of PD. PARK2 encodes an E3 ubiquitin ligase, Parkin, that can selectively translocate to dysfunctional mitochondria to promote their removal by autophagy. However, Parkin knockout (KO) mice do not display signs of neurodegeneration. To assess Parkin function in vivo, we utilized a mouse model that accumulates dysfunctional mitochondri ...[more]