Role of ?-catenin in development of bile ducts.
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ABSTRACT:
SUBMITTER: Cordi S
PROVIDER: S-EPMC4803532 | biostudies-literature | 2016 Jan-Mar
REPOSITORIES: biostudies-literature
Publications
Role of β-catenin in development of bile ducts.
Cordi Sabine S Godard Cécile C Saandi Thoueiba T Jacquemin Patrick P Monga Satdarshan P SP Colnot Sabine S Lemaigre Frédéric P FP
Differentiation; research in biological diversity 20160101 1-3
Beta-catenin is known to play stage- and cell-specific functions during liver development. However, its role in development of bile ducts has not yet been addressed. Here we used stage-specific in vivo gain- and loss-of-function approaches, as well as lineage tracing experiments in the mouse, to first demonstrate that β-catenin is dispensable for differentiation of liver precursor cells (hepatoblasts) to cholangiocyte precursors. Second, when β-catenin was depleted in the latter, maturation of c ...[more]
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