Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC6684151 | biostudies-literature | 2019 Mar-Jun
REPOSITORIES: biostudies-literature
Chen Yibin Y Devalliere Julie J Bulutoglu Beyza B Yarmush Martin L ML Uygun Basak E BE
Technology 20190301 1-2
Engineered liver grafts for transplantation with sufficient hepatic function have been developed both in small and large animal models using the whole liver engineering approach. However, repopulation of the bile ducts in the whole liver scaffolds has not been addressed yet. In this study, we show the feasibility of repopulating the bile ducts in decellularized rat livers. Biliary epithelial cells were introduced into the bile ducts of the decellularized liver scaffolds with or without hepatocyt ...[more]