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All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.


ABSTRACT: Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in the regulation of many cellular processes. A confirmed tumor suppressor protein, PP2A is genetically altered or functionally inactivated in many cancers highlighting a need for its therapeutic reactivation. In this review we discuss recent literature on PP2A: the elucidation of its structure and the functions of its subunits, and the identification of molecular lesions and post-translational modifications leading to its dysregulation in cancer. A final section will discuss the proteins and small molecules that modulate PP2A and how these might be used to target dysregulated forms of PP2A to treat cancers and other diseases.

SUBMITTER: Sangodkar J 

PROVIDER: S-EPMC4803620 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.

Sangodkar Jaya J   Farrington Caroline C CC   McClinch Kimberly K   Galsky Matthew D MD   Kastrinsky David B DB   Narla Goutham G  

The FEBS journal 20151114 6


Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase involved in the regulation of many cellular processes. A confirmed tumor suppressor protein, PP2A is genetically altered or functionally inactivated in many cancers highlighting a need for its therapeutic reactivation. In this review we discuss recent literature on PP2A: the elucidation of its structure and the functions of its subunits, and the identification of molecular lesions and post-translational modifications leading to its  ...[more]

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