Defining Appropriate Use of Proton-Pump Inhibitors Among Medical Inpatients.

ABSTRACT:

Background

Proton-pump inhibitors (PPIs) are commonly used among medical inpatients, both for prophylaxis against upper gastrointestinal bleeding (UGIB) and continuation of outpatient use. While PPIs reduce the risk of UGIB, they also appear to increase the risk of hospital-acquired pneumonia (HAP) and Clostridium difficile infection (CDI). Depending upon the underlying risks of these conditions and the changes in those risks with PPIs, use of proton-pump inhibitors may lead to a net benefit or net harm among medical inpatients.

Objective

We aimed to determine the net impact of PPIs on hospital mortality among medical inpatients.

Design

A microsimulation model, using literature-derived estimates of the risks of UGIB, HAP, and CDI among medical inpatients, along with t

SUBMITTER: Pappas M 

PROVIDER: S-EPMC4803704 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature