Ontology highlight
ABSTRACT:
SUBMITTER: Graham DY
PROVIDER: S-EPMC6913203 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Graham David Y DY Tansel Aylin A
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20170928 6
Although proton pump inhibitors (PPIs) are widely used, their relative potency and ideal dosing regimens remain unclear. We analyzed data from randomized clinical trials that performed pH testing in patients receiving solid-dose PPI formulations (omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole) for a minimum of 5 days. We used omeprazole equivalency and the surrogate biomarker, percentage time pH > 4 over a 24-hour period (pH4time), to compare PPI effectiveness for different PP ...[more]