Progesterone for neuroprotection in pediatric traumatic brain injury.

ABSTRACT:

Objective

To provide an overview of the preclinical literature on progesterone for neuroprotection after traumatic brain injury and to describe unique features of developmental brain injury that should be considered when evaluating the therapeutic potential for progesterone treatment after pediatric traumatic brain injury.

Data sources

National Library of Medicine PubMed literature review.

Study selection

The mechanisms of neuroprotection by progesterone are reviewed, and the preclinical literature using progesterone treatment in adult animal models of traumatic brain injury is summarized. Unique features of the developing brain that could either enhance or limit the efficacy of neuroprotection by progesterone are discussed, and the limited preclinical literature usin

SUBMITTER: Robertson CL 

PROVIDER: S-EPMC4806367 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature