Ontology highlight
ABSTRACT:
SUBMITTER: Dyson HJ
PROVIDER: S-EPMC4807259 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Dyson H Jane HJ Wright Peter E PE
The Journal of biological chemistry 20160205 13
The transcriptional coactivators CREB-binding protein (CBP) and p300 undergo a particularly rich set of interactions with disordered and partly ordered partners, as a part of their ubiquitous role in facilitating transcription of genes. CBP and p300 contain a number of small structured domains that provide scaffolds for the interaction of disordered transactivation domains from a wide variety of partners, including p53, hypoxia-inducible factor 1α (HIF-1α), NF-κB, and STAT proteins, and are the ...[more]