Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC4807435 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Chen J J Malone S S Prince H M A HM Patterson K B KB Dumond J B JB
CPT: pharmacometrics & systems pharmacology 20160322 3
Physiological changes during pregnancy can affect drug pharmacokinetics. Here we present a population pharmacokinetic model to describe the longitudinal change of unbound lopinavir/ritonavir (LPV/RTV) PK parameters with gestational age, and to predict unbound LPV concentrations under different dosing regimens. The changes in apparent intrinsic clearances of LPV and RTV during pregnancy are described using an exponential function of gestational age. The unbound fractions of LPV/RTV are not signif ...[more]