Ontology highlight
ABSTRACT:
SUBMITTER: Roffe E
PROVIDER: S-EPMC4807493 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Roffê Ester E Marino Ana Paula M P APMP Weaver Joseph J Wan Wuzhou W de Araújo Fernanda F FF Hoffman Victoria V Santiago Helton C HC Murphy Philip M PM
Infection and immunity 20160324 4
Infectious agents are often considered potential triggers of chronic inflammatory disease, including autoimmunity; however, direct evidence is usually lacking. Here we show that following control of acute infection of mice with the myotropic Colombiana strain of Trypanosoma cruzi, parasites persisted in tissue at low levels associated with development of systemic necrotizing vasculitis. Lesions occurred in many but not all organs and tissues, with skeletal muscle arteries being the most severely ...[more]