Linking DNA Damage and Hormone Signaling Pathways in Cancer.
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ABSTRACT:
SUBMITTER: Schiewer MJ
PROVIDER: S-EPMC4808434 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Linking DNA Damage and Hormone Signaling Pathways in Cancer.
Schiewer Matthew J MJ Knudsen Karen E KE
Trends in endocrinology and metabolism: TEM 20160301 4
DNA damage response and repair (DDR) is a tightly controlled process that serves as a barrier to tumorigenesis. Consequently, DDR is frequently altered in human malignancy, and can be exploited for therapeutic gain either through molecularly targeted therapies or as a consequence of therapeutic agents that induce genotoxic stress. In select tumor types, steroid hormones and cognate receptors serve as major drivers of tumor development/progression, and as such are frequently targets of therapeuti ...[more]
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