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Neutrophil trails guide influenza-specific CD8? T cells in the airways.

ABSTRACT: During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8(+) T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8(+) T cell migration and localization in influenza-infected tissues.

SUBMITTER: Lim K

PROVIDER: S-EPMC4809646 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways.

Lim Kihong K Hyun Young-Min YM Lambert-Emo Kris K Capece Tara T Bae Seyeon S Miller Richard R Topham David J DJ Kim Minsoo M

Science (New York, N.Y.) 20150901 6252

During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocy ...[more]

PMID: 26339033

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