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Consolidating and Exploring Antibiotic Resistance Gene Data Resources.


ABSTRACT: The unrestricted use of antibiotics has resulted in rapid acquisition of antibiotic resistance (AR) and spread of multidrug-resistant (MDR) bacterial pathogens. With the advent of next-generation sequencing technologies and their application in understanding MDR pathogen dynamics, it has become imperative to unify AR gene data resources for easy accessibility for researchers. However, due to the absence of a centralized platform for AR gene resources, availability, consistency, and accuracy of information vary considerably across different databases. In this article, we explore existing AR gene data resources in order to make them more visible to the clinical microbiology community, to identify their limitations, and to propose potential solutions.

SUBMITTER: Xavier BB 

PROVIDER: S-EPMC4809949 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Consolidating and Exploring Antibiotic Resistance Gene Data Resources.

Xavier Basil Britto BB   Das Anupam J AJ   Cochrane Guy G   De Ganck Sandra S   Kumar-Singh Samir S   Aarestrup Frank Møller FM   Goossens Herman H   Malhotra-Kumar Surbhi S  

Journal of clinical microbiology 20160127 4


The unrestricted use of antibiotics has resulted in rapid acquisition of antibiotic resistance (AR) and spread of multidrug-resistant (MDR) bacterial pathogens. With the advent of next-generation sequencing technologies and their application in understanding MDR pathogen dynamics, it has become imperative to unify AR gene data resources for easy accessibility for researchers. However, due to the absence of a centralized platform for AR gene resources, availability, consistency, and accuracy of i  ...[more]

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