Ontology highlight
ABSTRACT:
SUBMITTER: Andrake MD
PROVIDER: S-EPMC4810031 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Annual review of virology 20151101 1
The retroviral integrases are virally encoded, specialized recombinases that catalyze the insertion of viral DNA into the host cell's DNA, a process that is essential for virus propagation. We have learned a great deal since the existence of an integrated form of retroviral DNA (the provirus) was first proposed by Howard Temin in 1964. Initial studies focused on the genetics and biochemistry of avian and murine virus DNA integration, but the pace of discovery increased substantially with advance ...[more]