Ontology highlight
ABSTRACT:
SUBMITTER: Hare S
PROVIDER: S-EPMC3395085 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Hare Stephen S Maertens Goedele N GN Cherepanov Peter P
The EMBO journal 20120511 13
Retroviral integrase (IN) is responsible for two consecutive reactions, which lead to insertion of a viral DNA copy into a host cell chromosome. Initially, the enzyme removes di- or trinucleotides from viral DNA ends to expose 3'-hydroxyls attached to the invariant CA dinucleotides (3'-processing reaction). Second, it inserts the processed 3'-viral DNA ends into host chromosomal DNA (strand transfer). Herein, we report a crystal structure of prototype foamy virus IN bound to viral DNA prior to 3 ...[more]